Journal
IMMUNOLOGICAL REVIEWS
Volume 273, Issue 1, Pages 156-179Publisher
WILEY
DOI: 10.1111/imr.12439
Keywords
monocytes/macrophages; dendritic cells; neutrophils; bacterial; fungal; lipid mediators
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Funding
- Connaught International Scholarship for Doctoral Students
- National Council for Science and Technology/Consejo Nacional de Ciencia y Tecnologia (CONACYT) of Mexico
- Canadian Institutes of Health Research [FDN-143202]
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Phagocytosis, the regulated uptake of large particles (>0.5 mu m in diameter), is essential for tissue homeostasis and is also an early, critical component of the innate immune response. Phagocytosis can be conceptually divided into three stages: phagosome, formation, maturation, and resolution. Each of these involves multiple reactions that require exquisite spatial and temporal orchestration. The molecular events underlying these stages are being unraveled and the current state of knowledge is briefly summarized in this article.
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