Journal
IMMUNOLOGICAL REVIEWS
Volume 270, Issue 1, Pages 20-31Publisher
WILEY
DOI: 10.1111/imr.12384
Keywords
IgA; evolution; homeostasis; immune regulation; microbiota
Categories
Funding
- JSPS
- Special Coordination Funds for Promoting Science and Technology of the Japanese Government
- Astellas Pharma Inc. in the Formation of Innovation Center for Fusion of Advanced Technologies Program
- [25293118]
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Immunoglobulin A (IgA), the most abundantly secreted antibody isotype in mammals, not only provides direct immune protection to neonates via maternal milk but also helps program the infant immune system by regulating the microbiota. IgA continues to maintain dynamic interactions with the gut microbiota throughout life and this influences immune system homeostasis as well as other physiological processes. The secretory IgA produced independently of T-cell selection are commonly referred to as natural or innate antibodies. Our studies have shown that innate-IgA, while effective at excluding microorganisms from the gut, does not promote mutualism with the microbiota in the same way as adaptive-IgA that is selected in T cell-dependent germinal center reactions. Adaptive-IgA fosters more advanced mutualism with the microbiota than innate-IgA by selecting and diversifying beneficial microbial communities. In this review, we suggest that the diversified microbiota resulting from adaptive-IgA pressure was pivotal in promoting ecological adaptability and speciation potential of mammals.
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