Journal
IMMUNOLOGICAL INVESTIGATIONS
Volume 46, Issue 2, Pages 201-220Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/08820139.2016.1248560
Keywords
Dengue; interleukin-10; meta-analysis; polymorphism; TNF-alpha
Categories
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
- Fundacao de Amparo a Pesquisa de Alagoas (FAPEAL) [20110906-011-0025-0080]
Ask authors/readers for more resources
Objective: This study determined whether tumor necrosis factor alpha (TNF-) and Interleukin-10 (IL-10) polymorphisms are associated with susceptibility to dengue.Methods: a systematic review with meta-analysis was conducted of the associations between the TNF- (-308G/A) and IL-10 (-819C/T) polymorphisms and dengue.Results: A total of eight case-controls studies involving 384 individuals with symptomatic dengue, 571 individuals with dengue hemorrhagic fever, and 995 healthy controls were considered in the meta-analysis. There was no significant association between TNF- (-308G/A) and IL-10 (-819C/T) polymorphism and dengue in overall population. However, stratifying meta-analysis by groups, the meta-analysis revealed association between the TNF- -308 G/G (OR: 1.62, CI: 1.02-2.57, p = 0.04) genotype and allele G (OR: 1.62, CI: 1.04-2.55, p = 0.03) that confers susceptibility to symptomatic dengue, while the TNF- -308 G/A genotype (OR: 0.69, CI = 0.39-0.99, p = 0.04) and allele A (OR: 0.64, CI: 0.41-1.00, p = 0.05) confers protection to symptomatic dengue. No difference was observed for the TNF- (-308) and IL-10 (-819C/T) polymorphisms in the comparisons of hemorrhagic dengue versus control and hemorrhagic dengue versus symptomatic dengue.Conclusion: This meta-analysis showed that TNF- (-308) polymorphism is associated with dengue symptomatic susceptibility.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available