Journal
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
Volume 12, Issue 42, Pages 10277-10283Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jpclett.1c03071
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Funding
- University of Lorraine
- French CNRS
- University of Palermo
- University of Alcala [2020/00256/001]
- French Research Ministry (MESRI) under the GAVO project
- CNRAS
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This study presents the first calculated G4 structure of the RG-1 RNA sequence in the SARS-CoV-2 genome, demonstrating its stability and potential interaction with G4 ligands inhibiting viral protein translation. The findings highlight the importance of RNA G4 structures in modulating viral biological activities.
Guanine quadruplex (G4) structures in the viral genome have a key role in modulating viruses' biological activity. While several DNA G4 structures have been experimentally resolved, RNA G4s are definitely less explored. We report the first calculated G4 structure of the RG-1 RNA sequence of SARS-CoV-2 genome, obtained by using a multiscale approach combining quantum and classical molecular modeling and corroborated by the excellent agreement between the corresponding calculated and experimental circular dichroism spectra. We prove the stability of the RG-1 G4 arrangement as well as its interaction with G4 ligands potentially inhibiting viral protein translation.
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