Journal
IMMUNOLOGIC RESEARCH
Volume 64, Issue 4, Pages 901-907Publisher
HUMANA PRESS INC
DOI: 10.1007/s12026-016-8804-z
Keywords
IBD; Interleukin; Expression; Immunoregulatory; Inflammation
Categories
Funding
- CONACYT (Mexico) [178925]
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The aim of the study was to characterize and quantify tissue gene and protein expression of IL-27 in ulcerative colitis (UC) and Crohn's disease (CD) patients. This is an observational and cross-sectional study. Fifty-four patients with IBD were studied: 27 active UC, 12 inactive UC, 10 active CD, and 5 inactive CD. All patients belonged to the Inflammatory Bowel Disease Clinic at the Instituto Nacional de Ciencias M,dicas y Nutricin. We found that IL-27 gene expression was significantly higher in active UC versus inactive UC group (P = 0.015). The IL-27 mRNA expression was increased in patients with active CD compared with inactive CD disease (P = 0.035). The percentage of IL-27 immunoreactive cells was higher in active UC versus active CD patients and non-inflamed tissue controls. The IL-27 was significantly elevated in active UC and CD patients, and it was associated with disease severity.
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