Journal
JOURNAL OF PHARMACY AND PHARMACOLOGY
Volume 74, Issue 5, Pages 681-710Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jpp/rgab098
Keywords
Azadirachta indica; diabetic complications; oxidative stress; carbohydrate digestive enzymes; glucose uptake
Categories
Funding
- JSS AHER
Ask authors/readers for more resources
The research provides a critical review on the pharmacological activities and phytochemistry of Azadirachta indica related to diabetes management, showing its potential as an antidiabetic herbal medicine. However, gaps in research indicate a need for further systematic evaluation.
Objective We aim to provide a critical review focused on the various pharmacological activities of Azadirachta indica A. Juss related to diabetes management. We also emphasise on phytochemistry and toxicology of A. indica, which could provide a comprehensive approach for plant-based drug development in future. Key findings From 2784 identified studies, only 83 were considered after double screening based on the inclusion criteria. Further, 63 pharmacological investigations were considered for review. Resultant studies deliberated on using different extracts and phytochemicals of A. indica on blood glucose level, lipid profile, oxidative stress, carbohydrate digestion enzymes, diabetic complications, glucose tolerance, and uptake of glucose. In the end, one can know the efficacy of A. indica as a potent antidiabetic herbal medicine. However, based on gaps in research, recommendations have been provided to evaluate A. indica. in a systematic manner to develop plant-based drugs, nutraceuticals, and to evaluate their clinical efficiency and safety against diabetes mellitus.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available