4.5 Article

Intradermal Administration of Influenza Vaccine with Trehalose and Pullulan-Based Dissolving Microneedle Arrays

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Complete protection by a single-dose skin patch-delivered SARS-CoV-2 spike vaccine

Christopher L. D. McMillan et al.

Summary: The study demonstrates the use of high-density microarray patch (HD-MAP) for delivering a SARS-CoV-2 spike subunit vaccine directly to the skin, showing that the vaccine is stable on the patches and enhances both cellular and antibody immune responses. Furthermore, antibodies elicited by the vaccine can potently neutralize clinically relevant isolates including the Alpha and Beta variants, providing complete protection in a mouse model with a single dose of the HD-MAP-delivered spike vaccine.

SCIENCE ADVANCES (2021)

Article Pharmacology & Pharmacy

Engineering of an automated nano-droplet dispensing system for fabrication of antigen-loaded dissolving microneedle arrays

Jihui Lee et al.

Summary: A reproducible fabrication method for dissolving microneedle arrays (dMNAs) has been developed based on an automated nano-droplet dispensing system, which successfully minimized antigen waste. The system reduced the volume of antigen/polymer solution by 98.5% and shortened the production time by one day compared to centrifugation of the mold method.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Immunology

Intradermal vaccination of live attenuated influenza vaccine protects mice against homologous and heterologous influenza challenges

Andrew Chak-Yiu Lee et al.

Summary: Intradermal vaccination with DelNS1-LAIV provides potent and long-lasting protection against lethal virus challenge in mice, reducing viral load, epithelial cell death, and inflammatory responses. Activation of antigen-presenting cells and strong immunogenicity suggest that antibody responses play a key role in the protection induced by intradermal DelNS1-LAIV, offering an alternative route for LAIV administration.

NPJ VACCINES (2021)

Article Pharmacology & Pharmacy

Development of an Orodispersible Film Containing Stabilized Influenza Vaccine

Yu Tian et al.

PHARMACEUTICS (2020)

Article Pharmacology & Pharmacy

Vaccination with influenza hemagglutinin-loaded ceramic nanoporous microneedle arrays induces protective immune responses

Bert Schepens et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2019)

Review Engineering, Biomedical

Technology update: dissolvable microneedle patches for vaccine delivery

Aoife M. Rodgers et al.

MEDICAL DEVICES-EVIDENCE AND RESEARCH (2019)

Article Pharmacology & Pharmacy

Orodispersible films based on blends of trehalose and pullulan for protein delivery

Yu Tian et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Article Pharmacology & Pharmacy

Passive inhalation of dry powder influenza vaccine formulations completely protects chickens against H5N1 lethal viral challenge

Jasmine Tomar et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2018)

Review Pharmacology & Pharmacy

How sugars protect proteins in the solid state and during drying (review): Mechanisms of stabilization in relation to stress conditions

Maarten A. Mensink et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2017)

Review Immunology

Vaccine approaches conferring cross-protection against influenza viruses

Sai V. Vemula et al.

EXPERT REVIEW OF VACCINES (2017)

Article Pharmacology & Pharmacy

Formulation and characterisation of dissolving microneedles for the transdermal delivery of therapeutic peptides

Colin Dillon et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2017)

Article Medicine, Research & Experimental

Dissolving microneedles for transdermal drug delivery: Advances and challenges

Kevin Ita

BIOMEDICINE & PHARMACOTHERAPY (2017)

Article Chemistry, Multidisciplinary

Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches

Leonard Y. Chu et al.

PHARMACEUTICAL RESEARCH (2016)

Article Chemistry, Physical

The Role of Trehalose for the Stabilization of Proteins

Christoffer Olsson et al.

JOURNAL OF PHYSICAL CHEMISTRY B (2016)

Article Chemistry, Multidisciplinary

IgG-loaded hyaluronan-based dissolving microneedles for intradermal protein delivery

Juha Monkare et al.

JOURNAL OF CONTROLLED RELEASE (2015)

Article Medicine, Research & Experimental

Size and Molecular Flexibility of Sugars Determine the Storage Stability of Freeze-Dried Proteins

W. F. Tonnis et al.

MOLECULAR PHARMACEUTICS (2015)

Article Pharmacology & Pharmacy

Production of dissolvable microneedles using an atomised spray process: Effect of microneedle composition on skin penetration

Marie G. McGrath et al.

EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS (2014)

Review Pharmacology & Pharmacy

Microneedles for drug and vaccine delivery

Yeu-Chun Kim et al.

ADVANCED DRUG DELIVERY REVIEWS (2012)

Article Immunology

Microneedle and mucosal delivery of influenza vaccines

Sang-Moo Kang et al.

EXPERT REVIEW OF VACCINES (2012)

Article Chemistry, Medicinal

Dissolvable microneedle patches for the delivery of cell-culture-derived influenza vaccine antigens

Sushma Kommareddy et al.

JOURNAL OF PHARMACEUTICAL SCIENCES (2012)

Article Chemistry, Multidisciplinary

Dissolving Microneedle Patch for Transdermal Delivery of Human Growth Hormone

Jeong Woo Lee et al.

SMALL (2011)

Article Biochemistry & Molecular Biology

Dissolving polymer microneedle patches for influenza vaccination

Sean P. Sullivan et al.

NATURE MEDICINE (2010)

Article Multidisciplinary Sciences

Induction of Broadly Neutralizing H1N1 Influenza Antibodies by Vaccination

Chih-Jen Wei et al.

SCIENCE (2010)

Article Biochemistry & Molecular Biology

Dependence of the mechanical properties of a pullulan film on the preparation temperature

M Kawahara et al.

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2003)