4.5 Article

Development of Physiologically Based Pharmacokinetic Model for Pregabalin to Predict the Pharmacokinetics in Pediatric Patients with Renal Impairment and Adjust Dosage Regimens PBPK Model of Pregabalin in Pediatric Patients with Renal Impairment

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Application of physiologically based pharmacokinetic modeling to predict the pharmacokinetics of telavancin in obesity with renal impairment

Wanhong Wu et al.

Summary: The study developed a physiologically based pharmacokinetic (PBPK) model of telavancin to design optimized dosing regimens for obese patients with hospital-acquired pneumonia (HAP). Results showed that dose adjustments for obese patients should be based on renal function rather than total body weight according to the model.

EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Developing a physiologically based pharmacokinetic model of apixaban to predict scenarios of drug-drug interactions, renal impairment and paediatric populations

Ruijuan Xu et al.

Summary: The study successfully utilized a PBPK model to predict the pharmacokinetic profiles of apixaban under different conditions, and found that exposure to apixaban varies with interacting drugs or renal impairment. The results suggest that different populations may require different dosages when using apixaban.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2021)

Article Chemistry, Medicinal

Dosage Adjustment for Ceftazidime in Pediatric Patients With Renal Impairment Using Physiologically Based Pharmacokinetic Modeling

Jie Zhou et al.

Summary: Physiologically based pharmacokinetic modeling is advantageous for investigating drug pharmacokinetics in special populations, such as designing optimized dosing regimens for renally-impaired pediatric patients as demonstrated in this study for ceftazidime. The models accurately predicted drug exposures, adjusted dosages based on pharmacokinetic data, and evaluated pharmacodynamics to support dosing recommendations for pediatric patients with varying degrees of renal impairment.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Article Pharmacology & Pharmacy

Estimation of Ontogeny Functions for Renal Transporters Using a Combined Population Pharmacokinetic and Physiology-Based Pharmacokinetic Approach: Application to OAT1,3

Sinziana Cristea et al.

Summary: The study proposed a popPBPK approach to estimate the functional ontogeny of renal transporters, with accurate predictions of renal clearance for different substrates across different ages. This novel method could be further explored for the study of functional ontogeny of other transporters.

AAPS JOURNAL (2021)

Article Pharmacology & Pharmacy

Dosing Recommendations for Pediatric Patients With Renal Impairment

Amer Al-Khouja et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2020)

Review Pharmacology & Pharmacy

Physiologically-based pharmacokinetic models for children: Starting to reach maturation?

Laurens F. M. Verscheijden et al.

PHARMACOLOGY & THERAPEUTICS (2020)

Review Urology & Nephrology

Modeling Exposure to Understand and Predict Kidney Injury

Zhenhong Li et al.

SEMINARS IN NEPHROLOGY (2019)

Article Pharmacology & Pharmacy

Pharmacokinetic considerations in pediatric pharmacotherapy

Sin Yin Lim et al.

AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY (2019)

Article Gastroenterology & Hepatology

Randomised clinical trial: pregabalin vs placebo for irritable bowel syndrome

Yuri A. Saito et al.

ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2019)

Article Health Care Sciences & Services

The Possible Preventive Role of Pregabalin in Postmastectomy Pain Syndrome: A Double-Blinded Randomized Controlled Trial

Raafat M. Reyad et al.

JOURNAL OF PAIN AND SYMPTOM MANAGEMENT (2019)

Article Pharmacology & Pharmacy

Pediatric Dose Selection and Utility of PBPK in Determining Dose

Ian E. Templeton et al.

AAPS JOURNAL (2018)

Article Engineering, Environmental

A Permeability-Limited Physiologically Based Pharmacokinetic (PBPK) Model for Perfluorooctanoic acid (PFOA) in Male Rats

Weixiao Cheng et al.

ENVIRONMENTAL SCIENCE & TECHNOLOGY (2017)

Article Medicine, General & Internal

Trial of Pregabalin for Acute and Chronic Sciatica

Stephanie Mathieson et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Article Chemistry, Analytical

Quantitation of pregabalin in dried blood spots and dried plasma spots by validated LC-MS/MS methods

Nada Kostic et al.

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS (2015)

Article Clinical Neurology

Pregabalin long-term treatment and assessment of discontinuation in patients with generalized anxiety disorder

Siegfried Kasper et al.

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2014)

Article Pediatrics

Off-Label Use of Drugs in Children

Daniel A. C. Frattarelli et al.

PEDIATRICS (2014)

Article Genetics & Heredity

Persistent pharmacokinetic challenges to pediatric drug development

Daniel P. Sage et al.

FRONTIERS IN GENETICS (2014)

Review Pharmacology & Pharmacy

A Comparison of the Pharmacokinetics and Pharmacodynamics of Pregabalin and Gabapentin

Howard N. Bockbrader et al.

CLINICAL PHARMACOKINETICS (2010)

Article Pharmacology & Pharmacy

Clinical Pharmacokinetics of Pregabalin in Healthy Volunteers

Howard N. Bockbrader et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2010)

Review Pharmacology & Pharmacy

Pharmacokinetic role of L-type amino acid transporters LAT1 and LAT2

Eva M. del Amo et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2008)

Article Pharmacology & Pharmacy

Mediation of highly concentrative uptake of pregabalin by L-type amino acid transport in Chinese hamster ovary and caco-2 cells

TZ Su et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)

Article Medicine, General & Internal

Long-term survival of children with end-stage renal disease

SP McDonald et al.

NEW ENGLAND JOURNAL OF MEDICINE (2004)

Article Pharmacology & Pharmacy

Pharmacokinetics of pregabalin in subjects with various degrees of renal function

EJ Randinitis et al.

JOURNAL OF CLINICAL PHARMACOLOGY (2003)