Journal
IMMUNITY
Volume 44, Issue 4, Pages 728-738Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2016.02.002
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Funding
- NIH [AI 106302, AI121394, AI113217]
- Sunshine Foundation
- UChicago Center for Translational Medicine
- UChicago Digestive Diseases Research Core Center [DK42086]
- F.A.R.E. (Food Allergy Research and Education)
- Burroughs Wellcome Fund
- F.A.R.E.
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Allergic disease affects millions. Despite many advances in our understanding of the immune systemin the past century, the physiologic underpinning for the existence of allergy remains largely mysterious. Food allergies, in particular, have increased dramatically in recent years, adding a new sense of urgency to unraveling this mystery. The concurrence of significant lifestyle changes in Western societies with increasing disease prevalence implies a causal link. Demographic variables that influence the composition and function of the commensal microbiota early in life seem to be most important. Identifying the evolutionary and physiologic foundations of allergic disease and defining what about our modern environment is responsible for its increased incidence will provide insights critical to the development of new approaches to prevention and treatment.
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