Journal
JOURNAL OF ORGANOMETALLIC CHEMISTRY
Volume 956, Issue -, Pages -Publisher
ELSEVIER SCIENCE SA
DOI: 10.1016/j.jorganchem.2021.122115
Keywords
Palladium Catalyst; Carbonylation; Propargyl diol; Amines; Acids
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A palladium-catalyzed double carbonylation reaction has been developed for the rapid construction of 4-oxo-4-(aryl/alkylamino)butanoic acid scaffolds, using benzene-1,3,5-triyl triformate (TFBen) as the CO surrogate. The reaction with aromatic and aliphatic primary amines proceeded well, yielding a variety of functionalized acids in high yields.
A palladium-catalyzed double carbonylation of propargyl diols with primary amines has been developed for the expedite construction of 4-oxo-4-(aryl/alkylamino)butanoic acid scaffolds. With benzene-1,3,5-triyl triformate (TFBen) as the CO surrogate, the reaction with aromatic and aliphatic primary amines proceeded well to give a variety of functionalized acids in high yields. (c) 2021 Elsevier B.V. All rights reserved.
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