Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 23, Pages 17197-17212Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02288
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Funding
- National Natural Science Foundation of China [22071266]
- Public Computing Cloud Platform, Renmin University of China
- Fundamental Research Funds for the Central Universities
- Research Funds of Renmin University of China [21XNLG04]
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The study developed a three-component assembly method under transition-metal-free and open-air conditions for the construction of various 5-amino NH-1,2,3-triazoles, offering a simple and widely applicable approach. It was also demonstrated that NH-1,2,3-triazoles can be smoothly converted to regiospecific N-2 alkylated 1,2,3-triazole products.
The development of methods for the assembly of 1,2,3-triazoles is an important topic due to the broad applications of this motif in various scientific fields. In this work, we demonstrate that the three-component assembly of alpha-CF3 carbonyls, NaN3, and amines was achieved for the selective construction of a variety of 5-amino NH-1,2,3-triazoles under transition-metal-free and open-air conditions. The method provides a general and operationally simple route to functionalized biologically important molecules including carbohydrates, nucleosides, and peptides and exhibits broad substrate scopes. We further demonstrate that the NH-1,2,3-triazoles can be smoothly converted to the regiospecific N-2 alkylated 1,2,3-triazole products. Mechanistic studies based on experiments and density functional theory calculations showed that this transformation proceeds via defluorination-initiated programmed substitution/cyclization/H-transfer to give the 4,5-difunctionalized captodative NH-1,2,3-triazole product.
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