Journal
IMMUNITY
Volume 45, Issue 3, Pages 461-463Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2016.09.004
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- NIEHS NIH HHS [T32 ES016645] Funding Source: Medline
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Obesity shifts the immune phenotype from M2 macrophage polarization to M1, which causes metabolic dysfunction. In this issue of Immunity, Kumamoto et al. (2016) identify a tissue-resident mononuclear phagocyte population that promotes weight gain and glucose intolerance but are defined by the M2 marker CD301b.
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