4.7 Article

Furoxan Incorporation into C-H Bonds Enabling Nitrogen-Containing Functional Group Installation into the Same

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 21, Pages 15807-15817

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01950

Keywords

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Funding

  1. JSPS KAKENHI [21K05054]
  2. Foundation of Kinoshita Memorial Enterprise
  3. Grants-in-Aid for Scientific Research [21K05054] Funding Source: KAKEN

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A novel C-C bond forming method has been developed, allowing for the incorporation of a furoxan ring into various types of C-H bonds. This method not only provides a concise route to alkylated furoxan derivatives, but also offers an efficient strategy for inserting nitrogen-containing functional groups into C-H bonds via transformation of the resulting furoxan ring.
A C-C bond forming method was developed, whereby a furoxan ring is incorporated into various types of C-H bonds. The protocol not only offers a concise synthetic route to a variety of alkylated furoxan derivatives but also provides an efficient strategy for the insertion of various nitrogen-containing functional groups into C-H bonds via transformation of the resultant furoxan ring.

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