KPF6-Mediated Esterification and Amidation of Carboxylic Acids

A novel KPF6-promoted green method has been developed for the synthesis of esters and amides. A wide range of carboxylic acids and alcohols or amines worked well under the developed reaction conditions, thus providing good to excellent (61-98%) yields of the corresponding esters and amides. The (61-98%) yields of the corresponding esters and amides. The method worked well with bioactive substrates such as cholesterol, levulinic acid, and linoleic acid. Wide substrate scope, operational simplicity, scalability, and sustainability make this protocol a practical and economically attractive approach for the preparation of ester and amides.

Automated summary

A novel green method promoted by KPF6 has been developed for the synthesis of esters and amides, providing good to excellent yields (61-98%) under a wide range of reaction conditions. The method shows good performance with bioactive substrates and offers operational simplicity and sustainability, making it a practical and economically attractive approach for preparing esters and amides.