Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 21, Pages 15689-15694Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01228
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- CSIR, New Delhi
- Science and Engineering Research Board (SERB), New Delhi [GAP-330326]
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This paper discusses the synthesis and potential applications of a novel triple G-C-T nucleobase amino acid building block with three recognition faces, offering wide-ranging possibilities for nucleic acid recognition and nucleic acid peptide/protein interaction studies.
This note reports the synthesis and peptide formation of a novel triple G-C-T nucleobase amino acid (NBA) building block featuring three recognition faces: DDA (G mimic), DAA (C mimic), and ADA (T mimic). Readily obtainable in multigram scale in a remarkably easy one-step reaction, this unique NBA building block offers scope for wide ranging applications for nucleic acid recognition and nucleic acid peptide/protein interaction studies.
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