4.7 Article

Stereoselective Palladium-Catalyzed Arylation of Exo-Glycals with Aryl Iodides

Journal

JOURNAL OF ORGANIC CHEMISTRY
Volume 87, Issue 1, Pages 524-530

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02533

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Funding

  1. Ministry of Research, Innovation, and Science Early Researcher Award (MRIS ERA)

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A novel methodology for the arylation of exo-glycals has been developed, allowing for the formation of Z-isomers in a stereoselective manner. The transformation demonstrated excellent functional group tolerance.
A novel methodology for the arylation of exo-glycals has been developed. A range of exo-glycals underwent reactions with aryl iodides in the presence of a palladium catalyst. The transformation proceeded in a stereoselective manner to afford Z-isomers. The developed transformation demonstrated excellent functional group tolerance.

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