Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 23, Pages 17294-17306Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c02431
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Funding
- National Natural Science Foundation of China [21901187, 21472140]
- Natural Science Foundation of Zhejiang Province [LY21B020001]
- Graduate Scientific Research Foundation of Wenzhou University [16202001025]
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A facile method for the synthesis of alpha-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones has been disclosed. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.
A facile method is disclosed for the synthesis of alpha-thio/selenocyanato ketones through regioselective C-H thio/selenocyanation of ketones. The advantages include the use of easily available starting materials, high efficiency, simple operation, and easy scale-up. Control experiments provide evidence that the reaction proceeded via a radical way, while kinetic isotope effect experiments reveal that the cleavage of the C-H bond serves as the rate-limiting step.
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