Journal
JOURNAL OF ORGANIC CHEMISTRY
Volume 86, Issue 21, Pages 15733-15742Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.joc.1c01682
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Funding
- National Natural Science Foundation of China [21702091, 21772051]
- Science and Technology Innovation Development Plan of Yantai [2020MSGY114]
- Yantai Double Hundred Plan
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An iodine-promoted one-pot cascade oxidative annulation reaction has been developed for the synthesis of chromone-fused-pyrrolo[2,1-a]isoquinolines and indolizino[8,7-b]indoles. This process involves a logical approach to the target compounds and functionalization of two different functional groups. Manipulations of different substrates demonstrate the versatility of this strategy.
An iodine-promoted one-pot cascade oxidative annulation reaction has been developed for the synthesis of chromone-fused-pyrrolo[2,1-a]isoquinolines and indolizino[8,7-b]indoles from o-acetylphenoxyacrylates, tetrahydroisoquinolines, and noreleagnines. This process underwent a logical approach to both chromone-fused-pyrrolo[2,1-a]isoquinolines and chromone-fused-indolizino[8,7-b]indoles isolamellarin derivatives. Manipulations of L-menthol and DL-alpha-tocopherol demonstrate the applications of this strategy.
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