Photo-Induced Cross-Dehydrogenative Alkylation of Heteroarenes with Alkanes under Aerobic Conditions

We report a Minisci-type cross-dehydrogenative alkylation in an aerobic atmosphere using abundant and inexpensive cerium chloride as a photocatalyst and air as an oxidant. This photoreaction exhibits excellent tolerance to functional groups and is suitable for both heteroarene and alkane substrates under mild conditions, generating the corresponding products in moderate-to-good yields. Our method provides an alternative approach for the late-stage functionalization of valuable substrates.

Automated summary

A Minisci-type cross-dehydrogenative alkylation was reported using cerium chloride as a photocatalyst and air as an oxidant, showing excellent tolerance to functional groups and suitability for both heteroarene and alkane substrates, providing an alternative approach for late-stage functionalization of valuable substrates.