Copper-Catalyzed Microwave-Expedited Oxyphosphorylation of Alkynes with Diethyl Phosphite and t-Butyl Hydroperoxide Synthesis of Densely Functionalized Phosphonylated Indenones

Treatment of alkynes with diethyl phosphite and t-butyl hydroperoxide in the presence of [Cu(MeCN)(4)]BF4 under microwave irradiation produced the oxyphosphorylation of the triple bond, giving rise to the corresponding beta-ketophosphonates in moderate-to-good yields. When the triple bond was conjugated to a carbonyl group bearing an aromatic ring, it led to the cyclization of the resulting ketone intermediate, producing eventually different phosphonylated indenones.

Automated summary

The study utilized microwave irradiation to promote the oxyphosphorylation of alkynes with diethyl phosphite and t-butyl hydroperoxide in the presence of [Cu(MeCN)(4)]BF4, yielding different phosphonylated indenones.