The Photocatalyst-Free Cross-Dehydrogenative Coupling Reaction Enabled by Visible-Light Direct Excitation of Substrate Xuan

A new photocatalyst-free strategy for the cross-dehydrogenative C-C and C-P coupling reaction has been described. This protocol provides a concise method to synthesize various 1-substituted tetrahydroisoquinoline (THIQ) derivatives enabled by visible-light direct excitation of substrates without using any photocatalyst. Moreover, a wide substrate scope demonstrated good synthetic versatility and practicality.

Automated summary

A new strategy for cross-dehydrogenative C-C and C-P coupling reaction without the use of a photocatalyst has been developed. This method allows for the synthesis of various 1-substituted tetrahydroisoquinoline derivatives through visible-light direct excitation of substrates. The broad substrate scope demonstrates good synthetic versatility and practicality.