Journal
IMMUNITY
Volume 45, Issue 5, Pages 999-1012Publisher
CELL PRESS
DOI: 10.1016/j.immuni.2016.10.023
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Funding
- NIH [R01 DK060027, T32 AI118692]
- NIH NIAID Division of Intramural Research
- Japan Society for the Promotion of Science
- Uehara Memorial Foundation
- American Diabetes Association [7-12-MN-51]
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Aire's primary mechanism of action is to regulate transcription of a battery of genes in medullary thymic epithelial cells ( mTECs) and, consequently, negative selection of effector T cells and positive selection of regulatory T cells. We found that Aire-deficient mice had expanded thymic and peripheral populations of perinatally generated IL-17A(+)V gamma 6(+) V delta 1(+)T cells, considered to be early responders'' to tissue stress and drivers of inflammatory reactions. Aire-dependent control of Ii7 expression in mTECs regulated the size of thymic IL-17A(+)V gamma 6(+) V delta 1(+)T compartments. In mice lacking Aire and gd T cells, certain tissues typically targeted in the `` Aire-less'' disease, notably the retina, were only minimally infiltrated. IL-17A(+)V gamma 6(+) V delta 1(+)T cells were present in the retina of wild-type mice and expanded very early in Aire-deficientmice. A putatively parallel population of IL-17A(+)V gamma 6(+) V delta 1(+)T cells was increased in humans lacking Aire. Thus, Aire exerts multi-faceted autoimmune control that extends to a population of innate-like T cells.
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