4.4 Article

An optimized and validated protocol for inducing chronic experimental autoimmune encephalomyelitis in C57BL/6J mice

Related references

Note: Only part of the references are listed.
Article Biochemical Research Methods

Titration of myelin oligodendrocyte glycoprotein (MOG) - Induced experimental autoimmune encephalomyelitis (EAE) model

Rina Aharoni et al.

Summary: By titrating the doses of MOG 35-55 peptide, MT H37Ra, and PTx during EAE induction, researchers were able to drastically reduce the amount of reagents used while maintaining similar disease manifestations, high disease incidence, and consistent disease course. This improved protocol may offer a more sensitive and cost-effective model for testing therapeutic modalities for MS.

JOURNAL OF NEUROSCIENCE METHODS (2021)

Review Pharmacology & Pharmacy

Failed, Interrupted, or Inconclusive Trials on Neuroprotective and Neuroregenerative Treatment Strategies in Multiple Sclerosis: Update 2015-2020

Niklas Huntemann et al.

Summary: Numerous drugs have been approved for treating multiple sclerosis in recent years, mainly focusing on immunomodulatory or immunosuppressive strategies rather than remyelination and neuroprotection. Neuroregenerative agents have shown potential in pre-clinical research and clinical trials, providing valuable insights into MS pathophysiology. Learning from failed trials can aid in translating pre-clinical findings into clinical applications for improved treatments.

DRUGS (2021)

Article Clinical Neurology

Symptomatology and symptomatic treatment in multiple sclerosis: Results from a nationwide MS registry

Paulus Stefan Rommer et al.

MULTIPLE SCLEROSIS JOURNAL (2019)

Review Food Science & Technology

Assays for Determining Pertussis Toxin Activity in Acellular Pertussis Vaccines

Kevin Markey et al.

TOXINS (2019)

Article Immunology

Obesity Promotes EAE Through IL-6 and CCL-2-Mediated T Cells Infiltration

Zhe Ji et al.

FRONTIERS IN IMMUNOLOGY (2019)

Article Cell Biology

Intermittent Fasting Confers Protection in CNS Autoimmunity by Altering the Gut Microbiota

Francesca Cignarella et al.

CELL METABOLISM (2018)

Article Biochemical Research Methods

Consistent induction of chronic experimental autoimmune encephalomyelitis in C57BL/6 mice for the longitudinal study of pathology and repair

Jonathan P. C. Hasselmann et al.

JOURNAL OF NEUROSCIENCE METHODS (2017)

Article Clinical Neurology

New insights into the burden and costs of multiple sclerosis in Europe

Gisela Kobelt et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Article Clinical Neurology

New insights into the burden and costs of multiple sclerosis in Europe

Gisela Kobelt et al.

MULTIPLE SCLEROSIS JOURNAL (2017)

Review Immunology

Live Imaging of Immune Responses in Experimental Models of Multiple Sclerosis

Barbara Rossi et al.

FRONTIERS IN IMMUNOLOGY (2016)

Article Immunology

Respiratory infection with a bacterial pathogen attenuates CNS autoimmunity through IL-10 induction

Sarah C. Edwards et al.

BRAIN BEHAVIOR AND IMMUNITY (2015)

Review Immunology

Immunopathology of multiple sclerosis

Calliope A. Dendrou et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Biochemistry & Molecular Biology

Effects of peptide fraction and counter ion on the development of clinical signs in experimental autoimmune encephalomyelitis

Anne I. Boullerne et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Multidisciplinary Sciences

Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells

Markus Kleinewietfeld et al.

NATURE (2013)

Article Cardiac & Cardiovascular Systems

Platelets Contribute to the Pathogenesis of Experimental Autoimmune Encephalomyelitis

Harald F. Langer et al.

CIRCULATION RESEARCH (2012)

Article Multidisciplinary Sciences

Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis

Yun Kyung Lee et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Immunology

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

J. M. Fletcher et al.

CLINICAL AND EXPERIMENTAL IMMUNOLOGY (2010)

News Item Multidisciplinary Sciences

POLICY Basel Declaration defends animal research

Alison Abbott

NATURE (2010)

Article Immunology

Sex differences in experimental autoimmune encephalomyelitis in multiple murine strains

TL Papenfuss et al.

JOURNAL OF NEUROIMMUNOLOGY (2004)