Journal
JOURNAL OF NEUROSCIENCE
Volume 42, Issue 14, Pages 2917-2929Publisher
SOC NEUROSCIENCE
DOI: 10.1523/JNEUROSCI.1604-21.2022
Keywords
adolescence; local field potential; monkey; neurophysiology; prefrontal cortex
Categories
Funding
- National Institute of Mental Health of the National Institutes of Health [R01 MH 117996, R01 MH 116675]
Ask authors/readers for more resources
Working memory ability continues to mature into adulthood in humans and nonhuman primates. Adolescent development is characterized by increased frontal firing rate in the delay period, but less is known about the coordinated activity between neurons. This study found that there was higher power in the gamma frequency range in both the cue and delay period in adolescents compared to adults. These changes were observed in various recording sites and could not be explained by performance differences.
Working memory ability continues to mature into adulthood in humans and nonhuman primates. At the single-neuron level, adolescent development is characterized by increased prefrontal firing rate in the delay period, but less is known about how coordinated activity between neurons is altered. Local field potentials (LFPs) provide a window into the computations conducted by the local network. To address the effects of adolescent development on LFP activity, three male rhesus monkeys were trained to perform an oculomotor delayed response task and tested at both the adolescent and adult stages. Simultaneous single-unit and LFP signals were recorded from areas 8a and 46 of the dorsolateral prefrontal cortex. In both the cue and delay period, power relative to baseline in the gamma frequency range (32-128 Hz) was higher in the adolescent than the adult stage. The changes between developmental stages could not be accounted for by differences in performance and were observed in more posterior as well as more anterior recording sites. In the adult stage, high-firing neurons were also more likely to reside at sites with strong gamma power increase from baseline. For both stages, the gamma power increase in the delay was selective for sites with neuron-encoding stimulus information in their spiking. Our results establish gamma power decrease to be a feature of prefrontal cortical maturation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available