Journal
JOURNAL OF NATURAL PRODUCTS
Volume 84, Issue 11, Pages 2945-2952Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.jnatprod.1c00776
Keywords
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Funding
- Key Science and Technology Project of Hainan Province [ZDKJ202018]
- National Natural Science Foundation of China [82173709]
- Guangdong Provincial-level Special Funds for Promoting High-quality Economic Development [2020032]
- Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) [GML2019ZD0406]
- Key-Area Research and Development Program of Guangdong Province [2020B1111030005]
- National Key Research and Development Program of China [2019YFC0312503]
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In this study, 11 new fusidane-type nortriterpenoids were isolated from a marine-derived fungus, and their structures and absolute configurations were determined using various methods. One of the compounds showed strong antibacterial activity against Staphylococcus aureus.
Simplifusidic acids A-K (1-11), 11 new fusidane-type nortriterpenoids, were isolated from the marine-derived fungus Simplicillium sp. SCSIO 41513. Compound 1 possessed an unprecedented fusidane triterpene skeleton with a 6/6/7/5/5 polycyclic system. Their structures were elucidated by spectroscopic methods, and their absolute configurations were further determined by quantum chemical calculations of ECD spectra, comparison of experimental ECD spectra, and single-crystal X-ray diffraction analysis. Compound 9 showed strong antibacterial activity toward Staphylococcus aureus with an MIC value of 0.078 mu g/mL. Their structure-bioactivity relationship was also discussed.
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