Journal
JOURNAL OF NANOMATERIALS
Volume 2021, Issue -, Pages -Publisher
HINDAWI LTD
DOI: 10.1155/2021/4639317
Keywords
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Funding
- National Natural Science Foundation of China [51803092, 51873087]
- General Research Project of Jiangsu Provincial Health Commission [H2018058]
- Natural Science Foundation of Jiangsu Province of China [BK20180490]
- Fundamental Research Funds for the Central Universities [30920130121001]
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD, China)
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The study successfully prepared a three-dimensional polyacrylonitrile nanofiber with uniform internally connected pore structure by adjusting parameters. The attachment of chitosan gives the material antibacterial effect and biocompatibility, making it suitable for wound healing.
Electrospinning has become a popular nanotechnology for the fabrication of tissue engineering scaffolds, which can precisely regulate fiber diameter and microstructure. Herein, we have prepared a three-dimensional polyacrylonitrile (PAN) nanofiber by liquid-assisted electrospinning. The spacing between PAN nanofibers can reach to 15-20 mu m, as the uniform internally connected pore structure can be formed, through the regulation of parameters. Furthermore, the chitosan attached to the as-prepared nanofibers gives the material antibacterial effect and increases its biocompatibility. Meanwhile, the special structure of chitosan also provides the possibility for further loading drugs in dressings in the future. This newly developed nanocomposite seems to be highly suitable for wound healing due to its unique properties of biodegradability, biocompatibility, and antimicrobial effectiveness.
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