Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1245, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2021.131073
Keywords
Arginine; Cocrystals; Crystal structure; Preferential enrichment; Enantiomeric resolution
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Funding
- JSPS KAKENHI [26248024]
- Japan Society for the Promotion of Science
- Grants-in-Aid for Scientific Research [26248024] Funding Source: KAKEN
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Two new hydrate cocrystals, (RS)-arginine-fumaric acid-H2O (2) and (S)-arginine-2 fumaric acid-H2O (3), obtained from the slow evaporation of saturated aqueous ethanol solution, play a crucial role in the enrichment of arginine in the mother liquor due to their unstable formation.
Two new hydrate cocrystals, (RS)-arginine-fumaric acid-H2O ( 2 ) and (S)-arginine-2 fumaric acid-H2O ( 3 ), were obtained by the slow evaporation of the saturated aqueous ethanol solution of a 1:1 mixture of S-enriched arginine (33% ee) and fumaric acid or (S)-arginine and fumaric acid, respectively. Cocrystals 2 and 3 possess an isostructural molecular organization containing homochiral 1D chains of arginine sim-ilar to that of the anhydrous cocrystal of (RS)-arginine-fumaric acid ( 1 ). The latter showed an efficient preferential enrichment (PE), a unique spontaneous enantiomeric resolution phenomenon by simple recrystallization from the highly supersaturated solution. The formation of unstable cocrystals 2 and 3 seems to have played a crucial role in the enrichment of arginine in the mother liquor under PE crystal-lization conditions. (c) 2021 Elsevier B.V. All rights reserved.
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