Journal
JOURNAL OF MOLECULAR STRUCTURE
Volume 1244, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.molstruc.2021.130989
Keywords
Azo dye; Pyrazole; Enzyme inhibition; Antioxidant activity; Metal complexes
Categories
Ask authors/readers for more resources
In this study, novel azo dye metal complexes were synthesized and tested for their biochemical properties, including antioxidant and enzyme inhibitory activities. The results showed that the Ru(II) complex exhibited the best inhibition values against GST, AChE, and BChE enzymes.
In this study, the novel azo dye Fe-II , Co-II , Zn-II , and Ru-II complexes with an azo dye ligand (L: (E)-4-((4-methoxyphenyl)diazenyl)-3-methyl-1H-pyrazol-5-amine) were synthesized. The structures of the complexes were characterized by FT-IR, elemental analysis, UV-Vis, mass spectra (Fe-II and Co-II ), NMR spectra (only diamagnetic Zn-II and Ru-II ), thermogravimetric and differential thermal analysis (TA-DTA). All of the newly synthesized compounds were tested for their biochemical properties, including enzyme inhibitory and antioxidant activities. According to the in vitro ABTS, DPPH, CUPRAC, and FRAP antioxidant methods, the ligand and its metal complexes showed close antioxidant activities to the standards (BHA, BHT, ascorbic acid, and alpha-tocopherol). Enzyme inhibitions of the metal complexes were investigated against glutathione S-transferase (GST), acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) enzymes. The best inhibition values (Ki) were observed for Ru(II) complex against GST (14.36 +/- 2.16 mu M), AChE (16.86 +/- 2.74 mu M), and BChE (14.12 +/- 2.04 mu M). (C) 2021 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available