Microwave-assisted synthesis of pyrano[2,3-c]-pyrazole derivatives and their anti-microbial, anti-malarial, anti-tubercular, and anti-cancer activities

We have described solvent-free preparation of new pyrano[2,3-c]-pyrazole-5-carbonitriles (1-10) from the reaction of 1,3-diketo ester, aryl hydrazine, aromatic aldehyde, and malononitrile catalyzed by Zinc triflate (which was recycled and reused up to five times) under microwave irradiation (MWI) at 80-120 degrees C. An augmented yield with shorter reaction times is the added advantage of the present work. All synthe-sized molecules were screened for anti-malarial, anti-microbial, anti-tuberculosis, and anti-cancer activ-ities. Most of the tested compounds exhibited prominent anti-bacterial and anti-malarial activity, and some analogs showed anti-cancer activity. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

This study describes a solvent-free method for the preparation of new pyrano[2,3-c]-pyrazole-5-carbonitriles catalyzed by Zinc triflate under microwave irradiation, with the added advantage of increased yield and shorter reaction times. The synthesized molecules were found to exhibit potential medicinal value in anti-malarial, anti-microbial, anti-tuberculosis, and anti-cancer activities.