Responsiveness assessment of cell cultures exposed to poly(tartaric acid) and its corresponding magnetic nanostructures

Cancer incidence is increasing progressively in recent years, and its wide distribution among younger generations raises even greater concerns. This caused an acceleration in the development of medicine by implementing modern methods for diagnosis, treatment, and therapy. In this context, polymer-functionalized magnetic nanomaterials evolved as helpful tools for both the medical and pharmacological fields. The present study reports the structural analysis and biocompatibility assessment of poly(tartaric acid) and its corresponding magnetic nanostructures. The current research aimed to elaborate a prelim-inary study on the responsiveness assessment of cell cultures exposed to these nanomaterials for future biomedical applications. Fourier-transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and X-ray photoelectron spectroscopy (XPS) highlighted the successful attachment of the polyester on the magnetite surface and the preparation of the core-shell magnetic nanostructures. Biochemical ex-periments were performed in vitro on three types of human cell lines: normal keratinocytes, lung carci-noma, and skin melanoma. Viability, membrane integrity, and oxidative analyses performed on the ob-tained nanostructures proved a great inhibitory potential against cancer cell lines and little to no harmful effect against normal cell lines. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

Recent years have seen a progressive increase in cancer incidence, particularly among younger generations. The development of modern methods for diagnosis, treatment, and therapy has been accelerated to tackle this issue. Polymer-functionalized magnetic nanomaterials have emerged as useful tools in the medical and pharmacological fields, showing great potential in inhibiting cancer cell lines with little to no harmful effects on normal cell lines.