4.7 Article

Synergetic effect of silver nanoparticles and thiram on lipid bilayers

Journal

JOURNAL OF MOLECULAR LIQUIDS
Volume 348, Issue -, Pages -

Publisher

ELSEVIER
DOI: 10.1016/j.molliq.2021.118406

Keywords

Lipid bilayer; Vesicles; Silver nanoparticles; Thiram

Funding

  1. Brazilian agency FAPESP [2018/22214-6, 2017/15019-0, 2020/12129-1]
  2. Brazilian agency CNPq
  3. Brazilian agency CAPES
  4. Brazilian agency INCT/INEO

Ask authors/readers for more resources

The excessive concentration of nanomaterials and pesticides can pose a risk to human health. This study evaluated the individual and mixture effects of silver nanoparticles and thiram pesticide on lipid bilayers. The results showed a synergetic effect of the mixture, leading to a loss of phase contrast intensity and rupture of the lipid bilayers.
The excessive concentration of nanomaterials and pesticides in industrial products, food, and in the environment can be a risk to human health. Exposure to these materials can occur through inhalation, dermal contact, or oral ingestion, which depends directly on the type of products we are exposed to. Extensive studies about the individual action of these compounds have been described. However, the effect of these mixtures (nanoparticles and pesticides, for instance) requires more investigation. Here, we evaluated by phase-contrast microscopy the individual and mixture effects of silver nanoparticles (AgNp) and thiram pesticide on mimetic systems of the lipid bilayer structure of the plasma membrane using DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine) giant unilamellar vesicles (GUVs). Besides, the effect of thiram pesticide on DPPC (1,2-dipalmitoyl-sn-glycero-3-phosphocholine) multilamellar vesicles containing AgNp (encapsulated) was also evaluated by surface-enhanced Raman scattering (SERS). The results showed a synergetic effect of the AgNp and thiram mixture, which lead to a loss of phase contrast intensity and rupture of the lipid bilayers. The synergetic effect was ascribed to the strong interaction AgNp-thiram through Ag-S bond formation. (C) 2021 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available