Journal
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
Volume 32, Issue 3, Pages 302-306Publisher
KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
DOI: 10.4014/jmb.2110.10039
Keywords
Oxindole; Streptomyces sp; structural elucidation; anti-angiogenic activity
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Funding
- National Research Foundation of Korea (NRF) [2021M3H9A103743912]
- KRIBB Research Initiative Program - Ministry of Science ICT (MSIT) [KGM5292221]
- Basic Science Research Program of the Ministry of Education of the Republic of Korea. [2021R1I1A2049704]
- National Research Foundation of Korea [2021R1I1A2049704] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This study isolated and characterized two new compounds from the culture extract of Streptomyces sp. RK85-270. The structures of these compounds were determined through spectroscopic and spectrometric analysis. One of the compounds exhibited anti-angiogenic activities against human cells. Further experiments revealed that it inhibits angiogenesis through a specific signaling pathway.
A chemical investigation of a culture extract from Streptomyces sp. RK85-270 led to the isolation and characterization of two new oxindoles, RK-270D (1) and E (2). The structures of 1 and 2 were determined by analyzing spectroscopic and spectrometric data from 1D and 2D NMR and High resolution electrospray ionization mass spectrometry (HRESIMS) experiments. Compound 1 exhibited anti-angiogenic activities against human umbilical vein endothelial cells (HUVECs) without cytotoxicity. Results of Western blot analysis revealed that 1 inhibits VEGF-induced angiogenesis in the HUVECs via VEGFR2/ p38 MAPK-mediated pathway.
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