Phytochemicals for the treatment of COVID-19

The coronavirus disease 2019 (COVID-19) pandemic has underscored the lack of approved drugs against acute viral diseases. Plants are considered inexhaustible sources of drugs for several diseases and clinical conditions, but plant-derived compounds have seen little success in the field of antivirals. Here, we present the case for the use of compounds from vascular plants, including alkaloids, flavonoids, polyphenols, and tannins, as antivirals, particularly for the treatment of COVID-19. We review current evidence for the use of these phytochemicals against SARS-CoV-2 infection and present their potential targets in the SARS-CoV-2 replication cycle.

Automated summary

Plants are considered as a potential source of drugs for various diseases, but plant-derived compounds have not been successful in antiviral treatments. This study suggests the use of compounds from vascular plants as potential antivirals, focusing on their potential targets against SARS-CoV-2 infection.