4.4 Article

Dual Skin-Whitening and Anti-wrinkle Function of Low-Molecular-Weight Fish Collagen

Journal

JOURNAL OF MEDICINAL FOOD
Volume 25, Issue 2, Pages 192-204

Publisher

MARY ANN LIEBERT, INC
DOI: 10.1089/jmf.2021.K.0124

Keywords

collagen; melanogenesis; photoaging; skin fibroblasts

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In this study, the protective effects of low-molecular-weight fish collagen from tilapia against melanogenesis and photoaging were investigated. The results showed that low-molecular-weight fish collagen activated collagen production-related pathways and suppressed melanogenesis-related pathways. This collagen also exhibited anti-inflammatory, antioxidant, and anti-melanogenesis activities, providing a potential natural anti-photoaging product.
In this study, we investigated the protective effects of low-molecular-weight fish collagen from tilapia against melanogenesis in melanocytes, ultraviolet B (UVB)-irradiated Hs27 skin fibroblasts, and hairless mice. We observed collagen production-related pathways in UVB-irradiated Hs27 skin fibroblasts and hairless mice, and the melanogenesis-related pathways in melanocyte and UVB-irradiated hairless mice. The collagen production-related pathways were activated in the UVB-irradiated Hs27 skin fibroblasts and hairless mice. In addition, UVB exposure stimulated the melanogenesis-related pathways in melanocytes and hairless mice. However, treatment with low-molecular-weight fish collagen significantly increased the messenger RNA expressions of collagen production-related factors and significantly decreased the production of cytokines. Furthermore, treatment with low-molecular-weight fish collagen suppressed melanogenesis by inhibiting glutathione synthesis and downregulating melanocyte-inducing transcription factor expression through the suppression of cyclic AMP/protein kinase A/cAMP-responsive binding protein signaling and nitric oxide production. Low-molecular-weight fish collagen exerts protective effects against UVB-induced photoaging, through anti-inflammatory, antioxidant, and anti-melanogenesis activities and could be used for developing effective natural anti-photoaging products.

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