Related references
Note: Only part of the references are listed.PROTAC-DB: an online database of PROTACs
Gaoqi Weng et al.
NUCLEIC ACIDS RESEARCH (2021)
Snapshots and ensembles of BTK and cIAP1 protein degrader ternary complexes
James Schiemer et al.
NATURE CHEMICAL BIOLOGY (2021)
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences
Stephen K. Burley et al.
NUCLEIC ACIDS RESEARCH (2021)
Rationalizing PROTAC-Mediated Ternary Complex Formation Using Rosetta
Nan Bai et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)
Antibody-Mediated Delivery of Chimeric BRD4 Degraders. Part 2: Improvement of In Vitro Antiproliferation Activity and In Vivo Antitumor Efficacy
Peter S. Dragovich et al.
JOURNAL OF MEDICINAL CHEMISTRY (2021)
Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues
Sarath Ramachandran et al.
CURRENT OPINION IN STRUCTURAL BIOLOGY (2021)
Targeted protein degraders crowd into the clinic
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2021)
Structure-Based Design of a Macrocyclic PROTAC
Andrea Testa et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2020)
Modeling protein-protein, protein-peptide, and protein-oligosaccharide complexes: CAPRI 7th edition
Marc F. Lensink et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2020)
Structural Insights into PROTAC-Mediated Degradation of BcI-xL
Chun-wa Chung et al.
ACS CHEMICAL BIOLOGY (2020)
Targeted Degradation of Oncogenic KRASG12C by VHL-Recruiting PROTACs
Michael J. Bond et al.
ACS CENTRAL SCIENCE (2020)
PRosettaC: Rosetta Based Modeling of PROTAC Mediated Ternary Complexes
Daniel Zaidman et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Improved Accuracy for Modeling PROTAC-Mediated Ternary Complex Formation and Targeted Protein Degradation via New In Silico Methodologies
Michael L. Drummond et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2020)
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development
Katherine A. Donovan et al.
CELL (2020)
Development of Dual and Selective Degraders of Cyclin-Dependent Kinases 4 and 6
Baishan Jiang et al.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2019)
In Silico Modeling of PROTAC-Mediated Ternary Complexes: Validation and Application
Michael L. Drummond et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Proteolysis targeting chimeras (PROTACs) in 'beyond rule-of-five' chemical space: Recent progress and future challenges
Scott D. Edmondson et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)
BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design
William Farnaby et al.
NATURE CHEMICAL BIOLOGY (2019)
Development of targeted protein degradation therapeutics
Philip P. Chamberlain et al.
NATURE CHEMICAL BIOLOGY (2019)
A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo
Longchuan Bai et al.
CANCER CELL (2019)
Targeted protein degradation: expanding the toolbox
Matthieu Schapira et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Comparative Assessment of Scoring Functions: The CASF-2016 Update
Minyi Su et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2019)
Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis Targeting Chimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable Tumor Regression
Yangbing Li et al.
JOURNAL OF MEDICINAL CHEMISTRY (2019)
Developing degraders: principles and perspectives on design and chemical space
Hannah J. Maple et al.
MEDCHEMCOMM (2019)
Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyI)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyppyrrolidine-2-carboxamide (VH298)
Pedro Soares et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds
Kwok-Ho Chan et al.
JOURNAL OF MEDICINAL CHEMISTRY (2018)
The challenge of modeling protein assemblies: the CASP12-CAPRI experiment
Marc F. Lensink et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2018)
Plasticity in binding confers selectivity in ligand-induced protein degradation
Radoslaw P. Nowak et al.
NATURE CHEMICAL BIOLOGY (2018)
Induced protein degradation: an emerging drug discovery paradigm
Ashton C. Lai et al.
NATURE REVIEWS DRUG DISCOVERY (2017)
Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors
Le Wang et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
Structural basis of PROTAC cooperative recognition for selective protein degradation
Morgan S. Gadd et al.
NATURE CHEMICAL BIOLOGY (2017)
VoroMQA: Assessment of protein structure quality using interatomic contact areas
Kliment Olechnovic et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2017)
DockQ: A Quality Measure for Protein-Protein Docking Models
Sankar Basu et al.
PLOS ONE (2016)
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Kanak Raina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4
Michael Zengerle et al.
ACS CHEMICAL BIOLOGY (2015)
Catalytic in vivo protein knockdown by small-molecule PROTACs
Daniel P. Bondeson et al.
NATURE CHEMICAL BIOLOGY (2015)
Phthalimide conjugation as a strategy for in vivo target protein degradation
Georg E. Winter et al.
SCIENCE (2015)
Structure-Guided Design and Optimization of Small Molecules Targeting the Protein Protein Interaction between the von Hippel- Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities
Carles Galdeano et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
Protein and ligand preparation: parameters, protocols, and influence on virtual screening enrichments
G. Madhavi Sastry et al.
JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2013)
BET Inhibition Silences Expression of MYCN and BCL2 and Induces Cytotoxicity in Neuroblastoma Tumor Models
Anastasia Wyce et al.
PLOS ONE (2013)
Clustering biomolecular complexes by residue contacts similarity
Joao P. G. L. M. Rodrigues et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2012)
Open Babel: An open chemical toolbox
Noel M. O'Boyle et al.
JOURNAL OF CHEMINFORMATICS (2011)
Software News and Update AutoDock Vina: Improving the Speed and Accuracy of Docking with a New Scoring Function, Efficient Optimization, and Multithreading
Oleg Trott et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2010)
Protein Knockdown Using Methyl Bestatin-Ligand Hybrid Molecules: Design and Synthesis of Inducers of Ubiquitination-Mediated Degradation of Cellular Retinoic Acid-Binding Proteins
Yukihiro Itoh et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2010)
Protein-protein docking benchmark version 4.0
Howook Hwang et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2010)
FRODOCK: a new approach for fast rotational protein-protein docking
Jose Ignacio Garzon et al.
BIOINFORMATICS (2009)
Targeted intracellular protein degradation induced by a small molecule: En route to chemical proteomics
Ashley R. Schneekloth et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2008)
Glide: A new approach for rapid, accurate docking and scoring. 1. Method and assessment of docking accuracy
RA Friesner et al.
JOURNAL OF MEDICINAL CHEMISTRY (2004)
Protein-protein docking with simultaneous optimization of rigid-body displacement and side-chain conformations
JJ Gray et al.
JOURNAL OF MOLECULAR BIOLOGY (2003)
Protacs: Chimeric molecules that target proteins to the Skp1-Cullin-F box complex for ubiquitination and degradation
KM Sakamoto et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Share Paper
