What is in Our Kit? An Analysis of Building Blocks Used in Medicinal Chemistry Parallel Libraries

Building blocks are the molecular foundations for drug molecule design. The building block is one of the determining factors of final compound qualities in any given medicinal chemistry campaign. Herein, we describe our analysis of the building blocks used in parallel library synthesis at AbbVie. The results gave insights into the synthetic tractability and accessibilities of building blocks used in medicinal chemistry. Furthermore, our analysis showed that opportunities still exist for the identification and future incorporation of underrepresented building blocks, even for commonly used reactions, to obtain intellectual and competitive advantages in drug discovery.

Automated summary

Building blocks are crucial in drug molecule design, playing a significant role in determining the quality of the final compound. Analysis of the building blocks used in medicinal chemistry can provide insights into synthetic tractability and accessibility, as well as identify opportunities for incorporating underrepresented building blocks to gain intellectual and competitive advantages in drug discovery.