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The variants of SARS-CoV-2 and the challenges of vaccines

Journal

JOURNAL OF MEDICAL VIROLOGY
Volume 94, Issue 4, Pages 1366-1372

Publisher

WILEY
DOI: 10.1002/jmv.27513

Keywords

COVID-19; SARS-CoV-2; spike protein; vaccines; variants

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The COVID-19 pandemic has caused severe losses worldwide, leading to a focus on vaccine development. The discovery of new virus variants has posed challenges to vaccine effectiveness, but utilizing vaccines effectively remains crucial in epidemic prevention and control.
Since the outbreak of coronavirus disease 2019 (COVID-19), countries all over the world have suffered severe losses. It affects not only human life and health but also the economy. In response to COVID-19, countries have made tremendous efforts to vaccine development. The newly discovered variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have brought major challenges to the effectiveness and research of vaccines. This article reviews the existing literature and summarizes the main variants of the SARS-CoV-2 and its impact on vaccines, and provides new ideas for the later development of vaccines. An excellent job in developing and applying vaccines will be an important measure for epidemic prevention and control.

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