4.7 Article

Seroepidemiology of enterovirus D68 infection in Kuala Lumpur, Malaysia between 2013 and 2015

Journal

JOURNAL OF MEDICAL VIROLOGY
Volume 94, Issue 6, Pages 2607-2612

Publisher

WILEY
DOI: 10.1002/jmv.27381

Keywords

enterovirus; epidemiology; immune responses; neutralization; pathogenesis; respiratory tract; enterovirus D68

Categories

Funding

  1. Ministry of Higher Education, Malaysia (Fundamental Research Grant Scheme) [FRGS/2/2014/SKK04/UPM/02/2]
  2. Universiti Malaya [RK018-2019]

Ask authors/readers for more resources

The seroepidemiology study of Enterovirus D68 in Kuala Lumpur, Malaysia reveals that older age groups have a higher seropositivity rate for EV-D68, especially post-September 2014. The low seropositivity rate observed in children aged 1-3 years suggests they are at risk for infection.
Enterovirus D68 (EV-D68) is an emerging respiratory pathogen since the 2014 outbreak in the United States. A low level of virus circulation has been reported in Kuala Lumpur, Malaysia, in the past. However, the extent of the infection in Malaysia is not known. In the present study, we determine the seroepidemiology of EV-D68 in Kuala Lumpur, Malaysia, before and after the United States outbreak in August 2014. A luciferase-based seroneutralization test was developed using a clone-derived prototype Fermon strain carrying a nanoluciferase marker. We screened the neutralization capacity of 450 serum samples from children and adults (1-89 years old) collected between 2013 and 2015. EV-D68 seropositivity increased with age, with children aged 1-3 showing significantly lower seroprevalence compared to adults. Multivariate analysis showed that older age groups 13-49 years (odds ratio [OR] = 4.78; 95% confidence interval [CI] = 2.69-8.49; p < 0.0001) and >= 50 years (OR = 3.83; 95% CI = 2.19-6.68; p < 0.0001) were more likely to be EV-D68 seropositive than children <13 years. Sampling post-September 2014 compared to pre-Sept 2014 also predicted seropositivity (OR = 1.66; 95% CI = 1.04-2.65). The presence of neutralizing antibodies against EV-D68 in the study population suggests that EV-D68 was circulating before 2014. A higher seropositivity post-September 2014 suggests that Malaysia also experienced an upsurge in EV-D68 infections after the United States outbreaks in August 2014. A low seropositivity rate observed in children, especially those aged 1-3 years old, suggests that they are at risk and should be prioritized for future vaccination.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available