4.7 Review

Advances in laboratory detection methods and technology application of SARS-CoV-2

Journal

JOURNAL OF MEDICAL VIROLOGY
Volume 94, Issue 4, Pages 1357-1365

Publisher

WILEY
DOI: 10.1002/jmv.27494

Keywords

antigen; NAAT; SARS-CoV-2; sequencing; serum

Categories

Funding

  1. Key Project of Provincial Ministry Co-construction, Health science and Technology Project Plan of Zhejiang Province [WKJ-ZJ-2128]
  2. Key Laboratory of Women's Reproductive Health Research of Zhejiang Province [ZDFY2020-RH-0006]
  3. National Natural Science Foundation of China [U20A20351]
  4. Key Research and Development Plan of Zhejiang Province [2021C03079]

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The global COVID-19 pandemic poses a serious threat to human life and health, emphasizing the importance of prompt laboratory diagnosis and source isolation. Choosing appropriate detection techniques can improve efficiency in disease diagnosis and treatment, aiding in the containment of infectious disease outbreaks.
At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is raging worldwide, and the coronavirus disease 2019 outbreak caused by SARS-CoV-2 seriously threatens the life and health of all humankind. There is no specific medicine for novel coronavirus yet. So, laboratory diagnoses of novel coronavirus as soon as possible and isolation of the source of infection play a vital role in preventing and controlling the epidemic. Therefore, selecting appropriate detection techniques and methods is particularly important to improve the efficiency of disease diagnosis and treatment and to curb the outbreak of infectious diseases. In this paper, virus nucleic acid, protein, and serum immunology were reviewed to provide a reference for further developing virus detection technology to provide better prevention and treatment strategies and research ideas for clinicians and researchers.

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