Journal
JOURNAL OF MAGNETIC RESONANCE
Volume 334, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.jmr.2021.107113
Keywords
DW-MRS; J-coupling; Frequency selective pulse; Polychromatic pulse; Lactate
Funding
- European Research Council (ERC) under the European Union [818266]
- European Research Council (ERC) [818266] Funding Source: European Research Council (ERC)
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The use of diffusion-weighted spin echo block and spectrally selective refocusing pulses can effectively suppress J-coupling effects, leading to approximately two-fold increase in lactate signal. Repeated measurements confirm that lactate diffusion-weighted signal attenuation is measured with an approximately twofold precision.
Measurement of lactate diffusion properties using diffusion-weighted magnetic resonance spectroscopy in vivo may allow elucidating brain lactate cellular compartmentation, which would be of great importance for neuroscience. However, measuring lactate signal is complicated by low signal-to-noise ratio due to low lactate concentration and J-modulation of its 1.3 ppm peak. In this work, we assess the benefits of using a diffusion-weighting spin echo block and spectrally selective refocusing pulses to suppress the effect of J-coupling on the 1.3 ppm lactate resonance, by not refocusing its coupling partner at 4.1 ppm. Two different kinds of spectrally selective pulses, either polychromatic or single-band, are evaluated in the mouse brain at 11.7 T. Almost complete suppression of J-modulation is shown, resulting in an approximately two-fold signal increase as compared to a reference STE-LASER sequence (for the specific diffusion times used in this work). Repeated measurements confirm that lactate diffusion-weighted signal attenuation is measured with an approximately twofold precision. (C) 2021 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
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