Preparation and Properties of Poly(D,L-lacticie-co-glycolide- co-ε-caprolactone)/1,4-Butanendimine Modified Poly(lactide-co-glycolide) Blend Porous Microspheres

Composite porous microspheres based on blends of poly(D,L-lactide-co-glycolide-co-epsilon-caprolactone) (PLGCL) and 1,4-butanediamine modified poly(D,L-lactide-co-glycolide) (BMPLGA) were prepared by using a combined solvent evaporation and particle leaching technique. The morphologies and porous structure of the PLGCL/BMPLGA microspheres were observed by using scanning electron microscopy (SEM). The in-vitro degradation behaviors and cytocompatibility were studied. The resultant microspheres showed a porous surface and a three-dimensional network structure with interconnecting pores. The changes of morphologies, pH value and mass loss during in-vitro degradation in phosphate buffered solution (PBS) at 37 degrees C indicated that the degradation rate of the BMPLGA was faster than that of the PLGCL in the PLGCL/BMPLGA blends. We suggest the PLGCL/BMPLGA porous microspheres were non-cytotoxic and showed excellent cytocompatibility. We suggest the PLGCL/BMPLGA porous polymeric microspheres have great potential for application for drugs delivery and tissue regeneration.

Automated summary

Composite porous microspheres based on blends of PLGCL and BMPLGA were prepared using solvent evaporation and particle leaching technique. The microspheres showed porous surface and excellent cytocompatibility, indicating potential for drug delivery and tissue regeneration applications.