4.1 Article

Molecular signalling involved in upper airway remodelling is enhanced in patients with obstructive sleep apnoea

Journal

JOURNAL OF LARYNGOLOGY AND OTOLOGY
Volume 136, Issue 11, Pages 1096-1104

Publisher

CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0022215121004722

Keywords

Sleep Apnea; Obstructive; Uvula; Airway Remodeling; Cytokines; Inflammation

Funding

  1. Ministry of Science and Technology [MOST 109-2314-B-303 -028]

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This study found that the molecular signalling involved in upper airway remodelling is enhanced in patients with obstructive sleep apnoea, leading to more severe inflammation and increased protein expression.
Objective This study aimed to elucidate whether molecular signalling involved in upper airway remodelling is enhanced in patients with obstructive sleep apnoea. Method Twenty patients with mild obstructive sleep apnoea (control group) and 40 patients with moderate to severe obstructive sleep apnoea (obstructive sleep apnoea group) who desired uvulopalatopharyngoplasty were recruited for the study. After uvulopalatopharyngoplasty, surgical specimens of the uvula were subjected to haematoxylin and eosin, Masson's trichrome and immunohistochemical staining. Western blot and reverse transcriptase-polymerase chain reaction were used to evaluate the protein and messenger RNA expressions. Results The obstructive sleep apnoea group showed more severe inflammation, increased collagen deposition and higher immunohistochemical staining intensity for TGF-ss and MMP-9 as well as higher protein and messenger RNA expression of MMP-9, VEGF, TGF-ss, p38 MAPK, SMAD 2/3, AKT and JNK in the uvula than control group. Conclusion Patients with obstructive sleep apnoea demonstrated more severe inflammation, increased airway remodelling, and increased protein and messenger RNA expression of pro-inflammatory and pro-fibrotic cytokines in the uvula than control participants.

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