Journal
JOURNAL OF INSECT PHYSIOLOGY
Volume 134, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.jinsphys.2021.104309
Keywords
Drosophila; Anchor; Intestinal stem cells; Proliferation; Differentiation; Homeostasis
Categories
Funding
- Fundamental Research Funds for the Central Universities [2572018AA25, 2018225019]
- Doctoral Scientific Research Start-up Fund for Shenyang Medical College [20186058]
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The adult Drosophila intestinal epithelium is tightly regulated by the G protein-coupled receptor Anchor to maintain homeostasis. Inactivation of anchor leads to aberrant activation of the JNK and Notch pathways, affecting stem cell differentiation and proliferation, ultimately causing sensitivity to environmental challenges.
The adult Drosophila intestinal epithelium must be tightly regulated to maintain regeneration and homeostasis. The dysregulation of the regenerative capacity is frequently associated with intestinal diseases such as inflammation and tumorigenesis. Here, we showed that the G protein-coupled receptor Anchor maintains Drosophila adult midgut homeostasis by restricting Jun-N-terminal kinase (JNK) and Notch pathway activity. anchor inactivation resulted in aberrant JNK pathway activation, which led to excessive enteroblast (EB) production and premature enterocyte (EC) differentiation. In addition, increased Notch levels promoted premature EC differentiation following the loss of anchor. This defect induced by the loss of anchor ultimately caused sensitivity to stress or environmental challenge in adult flies. Taken together, our results demonstrate that the activity of anchor is essential to coordinate stem cell differentiation and proliferation to maintain intestinal homeostasis.
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