4.5 Article

Slow-Release of Curcumin Induced by Core-Shell Mesoporous Silica Nanoparticles (MSNs) Modified MIL-100(Fe) Composite

Journal

Publisher

SPRINGER
DOI: 10.1007/s10904-022-02230-2

Keywords

Bio-MOF; Curcumin; Drug delivery; Mesoporous silica; MIL-100(Fe); Slow-release

Funding

  1. PNBP Universitas Sebelas Maret in the scheme Advanced Applied Research (PUT) project [260/UN27.22/HK.07.00/2021]

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This study aims to modify the stability and performance of bio-MOF as a carrier for hydrophobic drugs. By employing mesoporous silica nanoparticles, the MIL-100(Fe) was modified through core-shell architecture to provide a slow-release feature of curcumin. The composites showed improved stability and controlled release properties in acidic conditions.
As a biocompatible porous material, bio-MOF is a very promising material as a carrier for hydrophobic drugs, including curcumin. However, the stability of bio-MOF against water and humidity still needs to be improved; therefore, surface modifications are required. This study aims to modify the MIL-100(Fe)-based bio-MOF through core-shell architecture by employing mesoporous silica nanoparticles (MSNs or SiO2) for improving the stability and performance of MIL-100(Fe) to provide a slow-release feature of curcumin. The composites were synthesized via sonochemistry-assisted or mechanochemistry-assisted green protocol to form core-shell structure of MIL-100(Fe)@SiO2 (Composite-1) or SiO2@MIL-100(Fe) (Composite-2). Structural, textural, and morphological analyses, including XRD, FTIR, SEM, TEM, and N-2 adsorption-desorption, are discussed in this study to evaluate the composite formation. BET surface area of the MIL-100(Fe) decreased from 1197.45 m(2)/g to 565.63 and 823.70 m(2)/g after forming composite-1 and composite-2 with SiO2. The loading capacity, however, just increased slightly up to 97.89% after the modification. The presence of SiO2 as shell (composite-1) protects the MIL-100(Fe) from degradation under the acidic condition at pH 5.8 and can maintain the slow-release of curcumin. In contrast, the presence of SiO2 as core (composite-2) induces the sustained release due to faster degradation of MIL-100(Fe) in acidic condition. Both composites serve as a model for either sustained release or delayed release drug delivery systems.

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