Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 225, Issue 2, Pages 208-213Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiab491
Keywords
children; COVID-19; disease severity; infants; outcomes; RNAemia; SARS-CoV-2; viremia
Categories
Funding
- National Institutes of Health [AI131386]
- Nationwide Children's Hospital intramural funds
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The burden of coronavirus disease 2019 (COVID-19) in children is relatively small globally, but a subset of hospitalized children with diverse clinical manifestations have been found to have SARS-CoV-2 RNAemia, which is associated with higher rates of oxygen administration, admission to the intensive care unit, and longer hospitalization.
The burden of coronavirus disease 2019 (COVID-19) in children represents a fraction of cases worldwide, yet a subset of those infected are at risk for severe disease. We measured plasma severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA in a cohort of 103 children hospitalized with COVID-19 with diverse clinical manifestations. SARS-CoV-2 RNAemia was detected in 27 (26%) of these children, lasted for a median of 6 (interquartile range, 2-9) days, and was associated with higher rates of oxygen administration, admission to the intensive care unit, and longer hospitalization.
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