Journal
JOURNAL OF INFECTIOUS DISEASES
Volume 225, Issue 12, Pages 2229-2234Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/infdis/jiac054
Keywords
latent tuberculosis; type-2 diabetes mellitus; heterologous immunity; inflammatory diseases; innate immunity; low-grade inflammation
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Funding
- Swiss National Science Foundation (SNF) [177499, 201369, P 880]
- SNF [179571, BSSGI0_155851, 310030_200407]
- Swiss HIV Research Foundation.
- Swiss National Science Foundation (SNF) [310030_200407] Funding Source: Swiss National Science Foundation (SNF)
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This study investigated the link between LTBI and DM in people living with HIV. The results showed that LTBI significantly increased the risk of developing DM, which was robust across different adjustment and censoring techniques.
While an increased risk of active and latent tuberculosis infection (LTBI) in people with type-2 diabetes (DM) has been demonstrated, it is less well characterized whether LTBI is associated with an increased risk of developing DM. We investigated the link between LTBI and DM in people living with HIV in the Swiss HIV Cohort Study via time-dependent Cox proportional hazards models. We found that LTBI significantly increased the risk of developing DM (HR = 1.47), which was robust across different adjustment and censoring techniques. Our results thus suggest that LTBI may be associated with an increased risk of developing DM.
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