4.7 Article

Improving pharmacologically relevant properties of sulfasalazine loaded in y-cyclodextrin-based metal organic framework

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Affinity of Lipophilic Drugs to Mixed Lipid Aggregates in Simulated Gastrointestinal Fluids

Jonas Henrik Fagerberg et al.

Summary: Mixed lipid aggregates play a crucial role in drug solubilization and absorption, but their variability can present challenges in drug studies. The presence of mixed lipid aggregates in biorelevant dissolution media enhances the solubility of most compounds, with the impact on drug affinity dependent on the chemical class of the drug.

JOURNAL OF PHARMACEUTICAL SCIENCES (2021)

Review Chemistry, Inorganic & Nuclear

Towards applications of bioentities@MOFs in biomedicine

Miriam de J. Velasquez-Hernandez et al.

Summary: Metal-organic frameworks (MOFs) combined with biomacromolecules, viruses, and cells have emerged as novel biocomposites for various applications. The integration of biological entities into MOF matrices generates biocomposites with enhanced stability, resistance, selectivity, and controlled release. The post functionalization of MOF-based drug carriers with lipids is a potential approach to improve dispersion, stability, and circulation time in biological fluids.

COORDINATION CHEMISTRY REVIEWS (2021)

Article Chemistry, Organic

Host-guest chemistry of the sulfasalazine-β-cyclodextrin inclusion complex

M. Nazir Tahir et al.

Summary: The study provides insights into the molecular architecture and binding constant of the SLZ-beta-CD inclusion complex using various analytical techniques. It reveals the relative orientation and specific binding mode between SLZ and beta-CD. Moreover, immobilization of SLZ on a sensor chip using surface plasmon resonance spectroscopy completely prevents the formation of the inclusion complex with beta-CD.

TETRAHEDRON (2021)

Article Chemistry, Physical

Non-ionic surfactant vesicles as novel delivery systems for sulfasalazine: Evaluation of the physicochemical and cytotoxic properties

Mehrdad Aghaei et al.

Summary: Encapsulating sulfasalazine (SSZ) within a micellar/niosomal formulation enhances its anticancer efficacy by promoting apoptosis in cancer cell lines and improving its bioavailability.

JOURNAL OF MOLECULAR STRUCTURE (2021)

Article Pharmacology & Pharmacy

Solidification of volatile D-Limonene by cyclodextrin metal-organic framework for pulmonary delivery via dry powder inhalers: In vitro and in vivo evaluation

Yong Zhou et al.

Summary: D-Limonene was loaded into a biodegradable gamma-cyclodextrin metal-organic framework to improve its stability and achieve efficient pulmonary delivery, showing promise for the development of dry powder inhalers. The interaction between D-Limonene and gamma-CD-MOF was revealed through various characterizations and molecular docking studies. Aerosolization of D-Limonene@gamma-CD-MOF for inhalation demonstrated satisfactory results, with a significant increase in bioavailability compared to oral administration.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2021)

Article Chemistry, Multidisciplinary

Mitochondria-targeted ROS- and GSH-responsive diselenide-crosslinked polymer dots for programmable paclitaxel release

Seul Gi Kim et al.

Summary: The design of ROS- and GSH-responsive PTX-loaded polymer dot with mitochondria-targeting capability allows for selective release of PTX in cancer cells, leading to enhanced apoptosis and reduced effects on normal cells.

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY (2021)

Review Chemistry, Applied

Cyclodextrin-based delivery systems for chemotherapeutic anticancer drugs: A review

Bingren Tian et al.

CARBOHYDRATE POLYMERS (2020)

Review Pharmacology & Pharmacy

Release mechanisms and applications of drug delivery systems for extended-release

Shuying Wang et al.

EXPERT OPINION ON DRUG DELIVERY (2020)

Article Pharmacology & Pharmacy

Efficient incorporation and protection of lansoprazole in cyclodextrin metal-organic frameworks

Xue Li et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2020)

Review Materials Science, Biomaterials

Phenomenology of the Initial Burst Release of Drugs from PLGA Microparticles

Jin Yoo et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2020)

Article Polymer Science

A polymer coated MNP scaffold for targeted drug delivery and improvement of rheumatoid arthritis

Seyedeh Mina Malaekehpoor et al.

POLYMER CHEMISTRY (2020)

Article Chemistry, Multidisciplinary

Complex Formation of Cyclodextrins with Sulfasalazine in Buffer Solutions

D. Yu. Kuranov et al.

RUSSIAN JOURNAL OF GENERAL CHEMISTRY (2018)

Article Medicine, Research & Experimental

Encapsulation of Ibuprofen in CD-MOF and Related Bioavailability Studies

Karel J. Hartlieb et al.

MOLECULAR PHARMACEUTICS (2017)

Article Chemistry, Multidisciplinary

RPLC determination of acid dissociation constants and quantitative estimation for sulfasalazine

Hulya Yilmaz et al.

JOURNAL OF THE IRANIAN CHEMICAL SOCIETY (2016)

Review Pharmacology & Pharmacy

Polymeric-based particulate systems for delivery of therapeutic proteins

Muhammad Sajid Hamid Akash et al.

PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY (2016)

Article Pharmacology & Pharmacy

Development, characterization and evaluation of the dissolution profile of sulfasalazine suspensions

Mayre Aparecida Borges da Costa et al.

BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Article Pharmacology & Pharmacy

New biomimetic barrier Permeapad™ for efficient investigation of passive permeability of drugs

Massimiliano di Cagno et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2015)

Review Polymer Science

Natural and Synthetic Polymers as Drug Carriers for Delivery of Therapeutic Proteins

Muhammad Sajid Hamid Akash et al.

POLYMER REVIEWS (2015)

Article Pharmacology & Pharmacy

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids

Sarah Clarysse et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2011)

Article Chemistry, Multidisciplinary

Metal-Organic Frameworks from Edible Natural Products

Ronald A. Smaldone et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2010)

Article Pharmacology & Pharmacy

Dimensional changes, gel layer evolution and drug release studies in hydrophilic matrices loaded with drugs of different solubility

Manuel Efentakis et al.

INTERNATIONAL JOURNAL OF PHARMACEUTICS (2007)