Journal
JOURNAL OF IMMUNOLOGY
Volume 207, Issue 11, Pages 2770-2784Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.2100469
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Funding
- National Natural Science Foundation of China [31822057]
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Circular RNAs are important regulators in the antiviral immune response of teleost fish, acting as competing endogenous RNA to enhance immune response by adsorbing miR-29a-3p and inhibiting viral replication.
Circular RNAs (circRNAs) are a subgroup of endogenous noncoding RNA that is covalently closed rings and widely expressed. In recent years, there is accumulating evidence indicating that circRNAs are a class of important regulators, which play an important role in various biological processes. However, the biological functions and regulation mechanism of circRNAs in lower vertebrates are little known. In this study, we discovered a circRNA Samd4a (circSamd4a) that is related to the antiviral immune response of teleost fish. It can act as a key regulator of the host's antiviral response and play a key role in inhibiting Sininiperca chuatsi rhabdovirus replication. Further studies have shown that circSamd4a may act as a competing endogenous RNA, which can enhance the STING-mediated NF-kappa B/IRF3 signaling pathway by adsorbing miR-29a-3p, thereby enhancing the antiviral immune response. Therefore, circSamd4a plays an active regulatory role in the antiviral immune response of bony fish. Our research results provide a strong foundation for circular RNA to play a regulatory role in the antiviral immune response of teleost fish.
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