Progress in preeclampsia: the contribution of animal models

Recent advances have been made in understanding the nature of placental dysfunction causing preeclampsia, and other hypertensive disorders of pregnancy. The contribution of animal studies in the understanding of the effects of inadequate placentation on blood pressure and other target organs will be explored in this review. This will include technical aspects of animal studies in pregnancy, as well as the translation of data regarding newly discovered pathological pathways, in particular the angiogenic pathway, into targets in clinical practice.

Automated summary

This review discusses recent advances in understanding the nature of placental dysfunction causing preeclampsia and other hypertensive disorders of pregnancy, specifically focusing on the contributions of animal studies. The translation of data regarding newly discovered pathological pathways, particularly the angiogenic pathway, into clinical practice is also discussed.