Disinfection methods against SARS-CoV-2: a systematic review

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019, has caused millions of deaths worldwide. The virus is transmitted by inhalation of infectious particles suspended in the air, direct deposition on mucous membranes and indirect contact via contaminated surfaces. Disinfection methods that can halt such transmission are important in this pandemic and in future viral infections. Aim: To highlight the efficacy of several disinfection methods against SARS-CoV-2 based on up-to-date evidence found in the literature. Methods: Two databases were searched to identify studies that assessed disinfection methods used against SARS-CoV-2. In total, 1229 studies were identified and 60 of these were included in this review. Quality assessment was evaluated by the Office of Health Assessment and Translation's risk-of-bias tool. Findings: Twenty-eight studies investigated disinfection methods on environmental surfaces, 16 studies investigated disinfection methods on biological surfaces, four studies investigated disinfection methods for airborne coronavirus, and 16 studies investigated methods used to recondition personal protective equipment (PPE). Conclusions: Several household and hospital disinfection agents and ultraviolet-C (UV-C) irradiation were effective for inactivation of SARS-CoV-2 on environmental surfaces. Formulations containing povidone-iodine can provide virucidal action on the skin and mucous membranes. In the case of hand hygiene, typical soap bars and alcohols can inactivate SARS-CoV-2. Air filtration systems incorporated with materials that possess catalytic properties, UV-C devices and heating systems can reduce airborne viral particles effectively. The decontamination of PPE can be conducted safely by heat and ozone treatment. (C) 2021 The Healthcare Infection Society. Published by Elsevier Ltd. All rights reserved.

Automated summary

This study reviews the efficacy of various disinfection methods against SARS-CoV-2 based on up-to-date evidence. The results show that several household and hospital disinfection agents, as well as ultraviolet-C (UV-C) irradiation, are effective in inactivating SARS-CoV-2 on environmental surfaces. Formulations containing povidone-iodine have a virucidal effect on the skin and mucous membranes. Typical soap bars and alcohols can inactivate SARS-CoV-2 for hand hygiene. Air filtration systems with catalytic properties, UV-C devices, and heating systems can effectively reduce airborne viral particles. Decontamination of personal protective equipment (PPE) can be safely conducted through heat and ozone treatment.